000			03833nam a22005175i 4500
001			978-1-4614-6166-1
003			DE-He213
005			20160302170752.0
007			cr nn 008mamaa
008			130220s2013 xxu| s |||| 0|eng d
020			_a9781461461661 _9978-1-4614-6166-1
024	7		_a10.1007/978-1-4614-6166-1 _2doi
050		4	_aQH573-671
072		7	_aPSF _2bicssc
072		7	_aSCI017000 _2bisacsh
072		7	_aSCI049000 _2bisacsh
082	0	4	_a571.9453 _223
245	1	0	_aStudies on Arthritis and Joint Disorders _h[electronic resource] / _cedited by Maria Jose Alcaraz, Oreste Gualillo, Olga S�nchez-Pernaute.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Humana Press, _c2013.
300			_aXII, 411 p. 41 illus., 15 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aOxidative Stress in Applied Basic Research and Clinical Practice
505	0		_aBiomarkers of oxidative stress in joint diseases -- Regulation of T-cell functions by oxidative stress -- Nitric oxide and the respiratory chain in synovial cells and chondrocytes -- Adipokines, molecular players at the crossroad between inflammation and oxidative stress. Role in arthropathies -- Regulation of cartilage and bone metabolism by oxidative stress -- Role of oxidative stress in bone aging -- Genetic Component of Oxidative Stress in Rheumatoid Arthritis -- Oxidative stress in rheumatoid arthritis -- Oxidative stress and premature atherosclerosis in RA -- Role of Oxidative Stress and Reactive Oxygen Radicals in the Pathogenesis of Systemic Sclerosis -- Antioxidant and anti-inflammatory properties of heme oxygenase-1 in osteoarthritic articular cells -- Oxidative stress at the crossroads between osteoarthritis and metabolic syndrome -- Metabolic syndrome and gout -- Natural Antioxidants in the pharmacological treatment of rheumatic immune and inflammatory diseases -- Antioxidants in the treatment of osteoarthritis and bone mineral loss -- Anti-cytokine agents to combat oxidative stress -- Oxidative Conditioning and treatment for Osteoarthritis -- The role of sirtuins in arthritis -- MicroRNA molecules, master regulators, biomarkers and potential therapies -- Estrogen-dependent transcriptional activity, a protection against ROS in osteoarthritis.
520			_aJoint diseases are a major public health concern. Reactive oxygen species are mediators in pathways associated with joint tissue injury. Oxidative Stress in Applied Basic Research and Clinical Practice: Studies on Arthritis and Joint Disorders provides background to understanding the role of reactive oxygen species in joint diseases, as well as therapeutic strategies for their regulation. International experts discuss recent advances on experimental and clinical data focused on free radical-mediated mechanisms of disease. The book also addresses the protective role of antioxidants against the insult of reactive oxygen species in rheumatic diseases.
650		0	_aLife sciences.
650		0	_aRheumatology.
650		0	_aCell biology.
650		0	_aOxidative stress.
650	1	4	_aLife Sciences.
650	2	4	_aOxidative Stress.
650	2	4	_aCell Biology.
650	2	4	_aRheumatology.
700	1		_aAlcaraz, Maria Jose. _eeditor.
700	1		_aGualillo, Oreste. _eeditor.
700	1		_aS�nchez-Pernaute, Olga. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461461654
830		0	_aOxidative Stress in Applied Basic Research and Clinical Practice
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-6166-1
912			_aZDB-2-SBL
999			_c197266 _d197266