TY  - BOOK
AU  - Rubin,Eric
AU  - Sakamoto,Kathleen
ED  - SpringerLink (Online service)
TI  - Modulation of Protein Stability in Cancer Therapy
SN  - 9780387691473
AV  - RC261-271 
U1  - 614.5999 23
PY  - 2009///
CY  - New York, NY
PB  - Springer US
KW  - Medicine
KW  - Cancer research
KW  - Human genetics
KW  - Immunology
KW  - Medical microbiology
KW  - Biochemistry
KW  - Biomedicine
KW  - Cancer Research
KW  - Medical Microbiology
KW  - Human Genetics
KW  - Biochemistry, general
N1  - Ubiquitin Ligases and Cancer -- The 26S Proteasome as a Therapeutic Target in Cancer: Beyond Protease Inhibitors? -- Targeting HAUSP: Killing Two Birds with One Stone -- Modulation of Protein Stability: Targeting the VHL Pathway -- Interrelationship of the Fanconi Anemia/BRCA Pathway -- Targeting the Sumoylation Pathway -- Proteasome Inhibitors -- Targeting Deubiquitinating Enzymes -- Proteolysis Targeting Chimeric Molecules
N2  - This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed. Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described
UR  - http://dx.doi.org/10.1007/978-0-387-69147-3
ER  -